AN NMR-STUDY OF EREMOMYCIN AND ITS DERIVATIVES FULL H-1 AND C-13 ASSIGNMENT, MOTIONAL BEHAVIOR, DIMERIZATION AND COMPLEXATION WITH AC-D-ALA-D-ALA

被引：34

作者：

BATTA, G

SZTARICSKAI, F

KOVER, KE

RUDEL, C

BERDNIKOVA, TF

机构：

[1] BIOGAL,PHARMACEUT WORKS,H-4010 DEBRECEN,HUNGARY

[2] RUHR UNIV BOCHUM,FAK CHEM,LEHRSTUHL ANALYT CHEM,W-4630 BOCHUM 1,GERMANY

[3] RUSSIAN ACAD MED SCI,INST NEW ANTIBIOT,MOSCOW 119867,RUSSIA

来源：

JOURNAL OF ANTIBIOTICS | 1991年 / 44卷 / 11期

关键词：

D O I：

10.7164/antibiotics.44.1208

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Complete H-1 and C-13 NMR assignments are presented for eremomycin (1) and some of its desglycosylated derivatives 2, 3 and compared to the structurally closely related glycopeptide vancomycin. Primary structure and stereochemistry of eremomycin is corroborated by the present high field total correlation spectroscopy, NOESY and heteronuclear multiple-bond correlation NMR methods. A rough motional characterization of the title compound is attempted by C-13-T1 and C-13-{H-1} NOE measurements. Dimerization of eremomycin is observed both in DMSO-d6-CCl4 and D2O solutions. Complexation with cell wall analogue dipeptide Ac-D-Ala-D-Ala is also demonstrated.

引用

页码：1208 / 1221

页数：14

共 29 条

[1] AN APPROACH TO OLIGOSACCHARIDE SEQUENCING - 2D NMR DEPT EXPERIMENT FOR DETECTION OF INTERGLYCOSIDIC C-13-H-1 SPIN-SPIN COUPLINGS [J].