ENDOTHELIN-1-LIKE AND ENDOTHELIN-3-LIKE IMMUNOREACTIVITY IN HUMAN CEREBROSPINAL-FLUID

被引：10

作者：

ANDO, K

HIRATA, Y ^{[1
]}

TOGASHI, K

KAWAKAMI, M

MARUMO, F

机构：

[1] TOKYO MED & DENT UNIV,DEPT INTERNAL MED 2,DIV ENDOCRINE,1-5-45 YUSHIMA,BUNKYO KU,TOKYO 113,JAPAN

[2] SMI BRISTOL LTD,KITASATO BIOCHEM LABS,TOKYO,JAPAN

[3] KITASATO UNIV,SCH MED,DEPT MOLEC BIOL,SAGAMIHARA,KANAGAWA 228,JAPAN

来源：

JOURNAL OF CARDIOVASCULAR PHARMACOLOGY | 1991年 / 17卷

关键词：

ENDOTHELIN-1; ENDOTHELIN-3; HUMAN CEREBROSPINAL FLUID; RADIOIMMUNOASSAY;

D O I：

10.1097/00005344-199100177-00124

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Using highly specific and sensitive radioimmunoassays (RIAs) for endothelin-1 (ET-1) and endothelin-3 (ET-3), we have determined the concentrations of ET-1- and ET-3-like immunoreactivities (LI) in human cerebrospinal fluid (CSF). The concentration of ET-3-LI (82.5 +/- 4.8 pg/ml) was about 1.5-fold greater than that of ET-1-LI (34.3 +/- 1.3 pg/ml). There was no significant correlation between ET-1-LI and ET-3-LI concentrations in human CSF (r = 0.44). Reverse-phase high-performance liquid chromatography (HPLC) revealed a single major component of ET-1-LI and ET-3-LI coeluting with authentic ET-1 and ET-3, respectively. It is suggested that ET-1 and ET-3 play a neuropeptide-like role in the central nervous system.

引用

收藏

页码：S434 / S436

页数：3

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