ABSOLUTE STEREOCHEMISTRY OF THE CALYCULINS, POTENT INHIBITORS OF PROTEIN-PHOSPHATASE-1 AND PROTEIN-PHOSPHATASE-2A

被引：51

作者：

MATSUNAGA, S ^{[1
]}

FUSETANI, N ^{[1
]}

机构：

[1] UNIV TOKYO,FAC AGR,MARINE BIOCHEM LAB,BUNKYO KU,TOKYO 113,JAPAN

来源：

TETRAHEDRON LETTERS | 1991年 / 32卷 / 40期

关键词：

D O I：

10.1016/0040-4039(91)80096-O

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A mixture of calyculins A, B, E, and F, which are geometric isomers at DELTA-2 and DELTA-6, was subjected to acid hydrolysis to obtain 2,3-dihydroxy-4-dimethylamino-5-methoxypentanoic acid (3), corresponding to the C33-C37 portion of the calyculins. A positive Cotton effect at 207 nm in the CD spectrum indicated 2S stereochemistry for 3, or 34S for the calyculins, thereby establishing the absolute configuration of the calyculins.

引用

页码：5605 / 5606

页数：2

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