GLYCOGEN-SYNTHASE KINASE-3 AND THE ALZHEIMER-LIKE STATE OF MICROTUBULE-ASSOCIATED PROTEIN TAU

被引：492

作者：

MANDELKOW, EM ^{[1
]}

DREWES, G ^{[1
]}

BIERNAT, J ^{[1
]}

GUSTKE, N ^{[1
]}

VANLINT, J ^{[1
]}

VANDENHEEDE, JR ^{[1
]}

MANDELKOW, E ^{[1
]}

机构：

[1] KU LEUVEN, AFDELING BIOCHEM, B-3000 LOUVAIN, BELGIUM

来源：

FEBS LETTERS | 1992年 / 314卷 / 03期

关键词：

PHOSPHORYLATION; MAP KINASE; PROTEIN KINASE-FA; PAIRED HELICAL FILAMENTS; SERINE-PROLINE MOTIFS;

D O I：

10.1016/0014-5793(92)81496-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Alzheimer-like state of tau protein includes phosphorylation by a proline-directed Ser/Thr kinase present in normal or pathological human brain. Extending earlier results on MAP kinase, we show here that the proline-directed kinase, GSK3, can induce an Alzheimer-like immune response involving several distinct and phoshorylatable epitopes at Ser-Pro motifs, as well as a gel mobility shift, similar to MAP kinase. Both kinases behave like microtubule-associated proteins in that they co-purify through cycles of assembly and disassembly, and both kinases are directly associated with paired helical filaments.

引用

页码：315 / 321

页数：7

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