NITRIC-OXIDE IS A MAJOR MEDIATOR IN REACTIVE HYPEREMIA EVOKED BY A BRIEF CORONARY-OCCLUSION IN THE GUINEA-PIG HEART

被引：17

作者：

CHLOPICKI, S

GRYGLEWSKI, RJ

机构：

[1] Department of Pharmacology, N. Copernicus University School of Medicine, 31-531 Kraków

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1993年 / 241卷 / 01期

关键词：

NITRIC OXIDE (NO); REACTIVE HYPEREMIA; HEART (GUINEA PIG);

D O I：

10.1016/0014-2999(93)90941-A

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In the isolated perfused guinea pig heart coronary occlusion lasting 1-5 s is followed by reactive hyperaemia which is inhibited by 91-100% after pretreatment with a NO synthase inhibitor, N(G)-nitro-L-arginine (100 muM). Neither indomethacin (5 muM) nor 8-phenyltheophylline (10 muM) influences these responses. Therefore, the brief cardiac reactive hyperaemia seems to be predominantly if not entirely mediated by nitric oxide (NO).

引用

收藏

页码：117 / 120

页数：4

相关论文

共 16 条

[1] SHEAR-STRESS INDUCED RELEASE OF NITRIC-OXIDE FROM ENDOTHELIAL-CELLS GROWN ON BEADS [J].

BUGA, GM ;

GOLD, ME ;

FUKUTO, JM ;

IGNARRO, LJ .

HYPERTENSION, 1991, 17 (02) :187-193

[2]

Chlopicki S, 1992, J Physiol Pharmacol, V43, P353

[3] REACTIVE HYPEREMIA IN DOG HEART - EFFECTS OF TEMPORARILY RESTRICTING ARTERIAL INFLOW AND OF CORONARY OCCLUSIONS LASTING ONE AND 2 CARDIAC CYCLES [J].

EIKENS, E ;

WILCKEN, DEL .

CIRCULATION RESEARCH, 1974, 35 (05) :702-712

[4]

FEIGL EO, 1983, PHYS REV, V63, P86

[5] MEASUREMENT OF CHANGES IN HIGH-ENERGY PHOSPHATES IN THE CARDIAC CYCLE BY USING GATED P-31 NUCLEAR MAGNETIC-RESONANCE [J].

FOSSEL, ET ;

MORGAN, HE ;

INGWALL, JS .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA-BIOLOGICAL SCIENCES, 1980, 77 (06) :3654-3658

[6] THE OBLIGATORY ROLE OF ENDOTHELIAL-CELLS IN THE RELAXATION OF ARTERIAL SMOOTH-MUSCLE BY ACETYLCHOLINE [J].

FURCHGOTT, RF ;

ZAWADZKI, JV .

NATURE, 1980, 288 (5789) :373-376

[7] REACTIVE HYPEREMIA IN DOG HEART - EVIDENCE FOR A MYOGENIC CONTRIBUTION [J].

GILES, RW ;

WILCKEN, DEL .

CARDIOVASCULAR RESEARCH, 1977, 11 (01) :64-73

[8] Quantitative relation between reactive hyperemia and the myocardial ischemia which it follows [J].

Katz, LN ;

Lindner, E .

AMERICAN JOURNAL OF PHYSIOLOGY, 1939, 126 (02) :283-288

[9] ROLE OF NITRIC-OXIDE IN REACTIVE HYPEREMIA OF THE GUINEA-PIG HEART [J].

KOSTIC, MM ;

SCHRADER, J .

CIRCULATION RESEARCH, 1992, 70 (01) :208-212

[10] L-NG-NITRO ARGININE (L-NOARG), A NOVEL, L-ARGININE-REVERSIBLE INHIBITOR OF ENDOTHELIUM-DEPENDENT VASODILATATION INVITRO [J].

MOORE, PK ;

ALSWAYEH, OA ;

CHONG, NWS ;

EVANS, RA ;

GIBSON, A .

BRITISH JOURNAL OF PHARMACOLOGY, 1990, 99 (02) :408-412