THE ENANTIOSELECTIVE SYNTHESIS OF AN IMPORTANT INTERMEDIATE TO THE ANTIVIRAL, (-)-CARBOVIR

被引：15

作者：

HANDA, S ^{[1
]}

EARLAM, GJ ^{[1
]}

GEARY, PJ ^{[1
]}

HAWES, JE ^{[1
]}

PHILLIPS, GT ^{[1
]}

PRYCE, RJ ^{[1
]}

RYBACK, G ^{[1
]}

SHEARS, JH ^{[1
]}

机构：

[1] SHELL RES LTD,SITTINGBOURNE RES CTR,SITTINGBOURNE ME9 8AG,KENT,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1994年 / 14期

关键词：

D O I：

10.1039/p19940001885

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two new routes to the important intermediate (-)-8 for the carbocyclic-based nucleosides are reported. The intermediate (-)-8 has also been synthesised in high enantiomeric excess via an enzymatic resolution of the racemic amide (+)-8 or an enzymatic hydrolysis of the meso diester 12.

引用

页码：1885 / 1886

页数：2

共 9 条

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