PORPHYRIN-NETROPSIN - A POTENTIAL LIGAND OF DNA

被引:36
作者
ANNEHEIMHERBELIN, G
PERREEFAUVET, M
GAUDEMER, A
HELISSEY, P
GIORGIRENAULT, S
GRESH, N
机构
[1] FAC SCI PHARMACEUT & BIOL PARIS,CNRS,CHIM THERAPEUT LAB,F-75270 PARIS 06,FRANCE
[2] INST BIOL PHYSICOCHIM,CNRS,BIOCHIM THEOR LAB,F-75005 PARIS,FRANCE
关键词
D O I
10.1016/S0040-4039(00)79304-X
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of a water-soluble cationic porphyrin bearing a netropsin motif on a glycine side arm is reported. Molecular modelling revealed that this molecule should exhibit good sequence-specific binding to DNA.
引用
收藏
页码:7263 / 7266
页数:4
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