THE EFFECT OF AGGLOMERATION METHODS ON THE MICROMERITIC PROPERTIES OF A MALTODEXTRIN PRODUCT, MALTRIN-150

被引:18
作者
LI, LC [1 ]
PECK, GE [1 ]
机构
[1] PURDUE UNIV,DEPT IND & PHYS PHARM,W LAFAYETTE,IN 47906
关键词
D O I
10.3109/03639049009074379
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
Maltrin M150 is a fine powder of maltodextrin which is a carbohydrate product made by controlled hydrolysis of corn starch. Agglomerated Maltrin was prepared using a fluidized bed granulation process and a roller compaction method, respectively. The micromeritic properties of these two granular products were compared. Three different sizes of granules (20/30, 40/50 and 80/100 mesh size) were used in the evaluation. Granules produced by the fluidized bed method showed a relatively low bulk density as compared to the roller compacted granules. As the granule size was reduced, the roller compacted granules showed a decrease in bulk density while an increase in bulk density was seen in the fluidized bed granulated product. A better flowability of the roller compacted granules was demonstrated by a higher flow rate and a lower compressibility index. For a given compression pressure, roller compacted granules produced compacts with a lower tensile strength. A significant work-hardening effect was exhibited by the roller compacted product. © 1990 Informa UK Ltd All rights reserved: reproduction in whole or part not permitted.
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页码:1491 / 1503
页数:13
相关论文
共 11 条
[1]  
Aulton ME, 1981, INT J PHARMTECH PROD, V1, P1
[2]   DETERMINATION OF TABLET STRENGTH BY DIAMETRAL-COMPRESSION TEST [J].
FELL, JT ;
NEWTON, JM .
JOURNAL OF PHARMACEUTICAL SCIENCES, 1970, 59 (05) :688-&
[3]  
HARDWOOD CF, 1968, J PHARM SCI, V57, P478
[4]  
HECKEL RW, 1961, T METALL SOC AIME, V221, P671
[5]  
HECKEL RW, 1961, T METALL SOC AIME, V221, P1001
[6]   RECORDING POWDER FLOW METERS AND THEIR USE IN PHARMACEUTICAL TECHNOLOGY [J].
JORDAN, RP ;
RHODES, CT .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1979, 5 (02) :151-167
[7]  
KHAN KA, 1973, CAN J PHARM SCI, V8, P1
[8]   EFFECT OF RE-COMPRESSION ON THE PROPERTIES OF TABLETS PREPARED BY DRY GRANULATION [J].
MALKOWSKA, S ;
KHAN, KA .
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 1983, 9 (03) :331-347
[9]  
Marshall K., 1986, THEORY PRACTICE IND, P67
[10]  
MCCURDY VE, 1985, THESIS PURDUE U W LA, V1