EFFECT OF A TUMOR PROMOTER, 12-O-TETRADECANOYL-PHORBOL-13-ACETATE (TPA), ON SISTER-CHROMATID EXCHANGE FORMATION IN CULTURED CHINESE-HAMSTER CELLS

被引：57

作者：

LOVEDAY, KS ^{[1
]}

LATT, SA ^{[1
]}

机构：

[1] HARVARD UNIV,SCH MED,DEPT PEDIAT,BOSTON,MA 02115

来源：

MUTATION RESEARCH | 1979年 / 67卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0165-1218(79)90030-2

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The tumor promoter 12-O-tetradecanoyl-phorbol-13-acetate (TPA) does not increase the sister-chromatid exchange (SCE) frequency in either Chinese hamster ovary (CHO) or lung (V 79) cells which are cultured in the presence of 5-bromodeoxyuridine. Moreover, TPA does not alter the induction of SCEs in CHO cells by mitomycin C during the first 3 cycles following addition of the alkylating agent. These SCE induction data do not by themselves support the hypothesis that tumor promotion by TPA depends on the enhancement of mitotic recombination. © 1979.

引用

页码：343 / 348

页数：6

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