PROSTAGLANDIN CHEMISTRY .35. SHORT SYNTHESIS OF ISOCARBACYCLIN BY REGIOSELECTIVE SN2' ALKYLATION OF BICYCLIC ALLYLIC ESTERS WITH ZINC-COPPER REAGENTS

被引：30

作者：

TANAKA, T

BANNAI, K

HAZATO, A

KOGA, M

KUROZUMI, S

KATO, Y

机构：

[1] Institute for Bio-Medical Research, Teijin Ltd., Hino, Tokyo, 191

来源：

TETRAHEDRON | 1991年 / 47卷 / 10-11期

关键词：

D O I：

10.1016/S0040-4020(01)96099-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Isocarbacyclin [(+)-9(O)-methano-DELTA-6(9-alpha)-prostaglandin I1] (2) was synthesized from bicyclic synthons such as 2-phosphorylated, 2-(thio)phosphorylated, 2-tosylated, 2-methoxycarbonylated, and 2-chloro-3-methylenebicyclo[3.3.0] octanes via highly regioselective S(N)2' alkylation with zinc-copper reagents 9 in excellent yields.

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页码：1861 / 1876

页数：16

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