TRANSGENIC THYMOCYTES ARE REFRACTORY TO TRANSFORMATION BY THE HUMAN T-CELL LEUKEMIA-VIRUS TYPE-I TAX GENE

被引：29

作者：

NERENBERG, MI ^{[1
]}

MINOR, T ^{[1
]}

PRICE, J ^{[1
]}

ERNST, DN ^{[1
]}

SHINOHARA, T ^{[1
]}

SCHWARZ, H ^{[1
]}

机构：

[1] SCRIPPS RES INST, DEPT IMMUNOL, LA JOLLA, CA 92037 USA

来源：

JOURNAL OF VIROLOGY | 1991年 / 65卷 / 06期

关键词：

D O I：

10.1128/JVI.65.6.3349-3353.1991

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Previous transgenic work demonstrated transforming activity of the human T-cell leukemia virus type I Tax protein in fibroblasts. In the present study, a Thy-1-based vector was used to express Tax in thymocytes. These mice developed no functional or neoplastic abnormalities of T cells but developed fibroblastic tumors with a longer latency than in the previous model.

引用

页码：3349 / 3353

页数：5

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