CD8+ LYMPHOCYTES-T AND PROGRESSION TO AIDS IN HIV-INFECTED MEN - SOME OBSERVATIONS

被引:35
作者
ANDERSON, RE
SHIBOSKI, SC
ROYCE, R
JEWELL, NP
LANG, W
WINKELSTEIN, W
机构
[1] UNIV CALIF BERKELEY,SCH PUBL HLTH,BERKELEY,CA 94720
[2] VIRX INC,SAN FRANCISCO,CA
[3] HARVARD UNIV,SCH PUBL HLTH,BOSTON,MA 02115
[4] CHILDRENS HOSP,SAN FRANCISCO,CA 94119
关键词
HIV-1; AIDS; CD8+ LYMPHOCYTES-T;
D O I
10.1097/00002030-199102000-00013
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The relationship between CD8+ lymphocyte counts and progression to AIDS was studied in 340 HIV-1-seropositive men participating in a population-based prospective study. Overall, the relative hazard for developing AIDS during 60 months of observation was slightly elevated (1.08, P = 0.003), indicating an 8% increase in risk of progression for every 100 CD8+ cell count increment. When the data were analyzed in relation to date of diagnosis, the relative hazard was depressed (0.90, P < 0.001) for the period 6 months prior to diagnosis, but was close to 1.0 for the period 6-36 months prior to diagnosis. These findings suggest a complex relationship between CD8+ cell counts and progression to AIDS, with the possibility that various subsets of the CD8+ compartment play different roles.
引用
收藏
页码:213 / 215
页数:3
相关论文
共 15 条
[1]  
ARMSTRONG JA, 1990, 4 INT C AIDS SAN FRA
[2]  
ASCHER MS, 1990, J ACQ IMMUN DEF SYND, V3, P177
[3]  
Cox DR, 1984, ANAL SURVIVAL DATA, pviii
[4]   THE PROGNOSTIC VALUE OF CELLULAR AND SEROLOGIC MARKERS IN INFECTION WITH HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 [J].
FAHEY, JL ;
TAYLOR, JMG ;
DETELS, R ;
HOFMANN, B ;
MELMED, R ;
NISHANIAN, P ;
GIORGI, JV .
NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (03) :166-172
[5]   A PROSPECTIVE-STUDY OF HUMAN IMMUNODEFICIENCY VIRUS TYPE-1 INFECTION AND THE DEVELOPMENT OF AIDS IN SUBJECTS WITH HEMOPHILIA [J].
GOEDERT, JJ ;
KESSLER, CM ;
ALEDORT, LM ;
BIGGAR, RJ ;
ANDES, WA ;
WHITE, GC ;
DRUMMOND, JE ;
VAIDYA, K ;
MANN, DL ;
EYSTER, ME ;
RAGNI, MV ;
LEDERMAN, MM ;
COHEN, AR ;
BRAY, GL ;
ROSENBERG, PS ;
FRIEDMAN, RM ;
HILGARTNER, MW ;
BLATTNER, WA ;
KRONER, B ;
GAIL, MH .
NEW ENGLAND JOURNAL OF MEDICINE, 1989, 321 (17) :1141-1148
[6]   PNEUMOCYSTIS-CARINII PNEUMONIA AND MUCOSAL CANDIDIASIS IN PREVIOUSLY HEALTHY HOMOSEXUAL MEN - EVIDENCE OF A NEW ACQUIRED CELLULAR IMMUNODEFICIENCY [J].
GOTTLIEB, MS ;
SCHROFF, R ;
SCHANKER, HM ;
WEISMAN, JD ;
FAN, PT ;
WOLF, RA ;
SAXON, A .
NEW ENGLAND JOURNAL OF MEDICINE, 1981, 305 (24) :1425-1431
[7]  
KANNAGI M, 1988, J IMMUNOL, V140, P2237
[8]  
KANNAGI M, 1990, 6 INT C AIDS SAN FRA
[9]   APPLICATION OF FLOW-CYTOMETRY TO THE STUDY OF HIV-INFECTION [J].
LANDAY, A ;
OHLSSONWILHELM, B ;
GIORGI, JV .
AIDS, 1990, 4 (06) :479-497
[10]  
LANDAY AL, 1990, 6 INT C AIDS SAN FRA