ANGIOGENIC EFFECTS OF ADVANCED GLYCATION END-PRODUCTS OF THE MAILLARD REACTION ON CULTURED HUMAN UMBILICAL-CORD VEIN ENDOTHELIAL-CELLS

被引：48

作者：

TEZUKA, M ^{[1
]}

KOYAMA, N ^{[1
]}

MORISAKI, N ^{[1
]}

SAITO, Y ^{[1
]}

YOSHIDA, S ^{[1
]}

ARAKI, N ^{[1
]}

HORIUCHI, S ^{[1
]}

机构：

[1] KUMAMOTO UNIV,SCH MED,DEPT BIOCHEM,KUMAMOTO 860,JAPAN

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 193卷 / 02期

关键词：

D O I：

10.1006/bbrc.1993.1677

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of advanced glycation end products (AGE) of the Maillard reaction on proliferation, migration and angiogenesis of cultured human umbilical vein endothlial cells (HUVEC) were studied. In an in vitro angiogenesis system, tube formation of HUVEC was dose-dependently stimulated by AGE at 0.5-50 μg/ml. Migration of HUVEC was also stimulated by AGE in a similar concentration range, and checkerboard analysis revealed that AGE were chemotactic but not chemokinetic. Proliferation of HUVEC was not affected by AGE. These data provide evidence that AGE are angiogenic. © 1993 Academic Press, Inc.

引用

页码：674 / 680

页数：7

共 16 条

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