THE EFFECT OF ONDANSETRON ON RADIATION-INDUCED EMESIS AND DIARRHEA

被引:31
作者
HENRIKSSON, R [1 ]
LOMBERG, H [1 ]
ISRAELSSON, G [1 ]
ZACKRISSON, B [1 ]
FRANZEN, L [1 ]
机构
[1] GLAXO SWEDEN AB,MOLNDAL,SWEDEN
关键词
D O I
10.3109/02841869209083868
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Fractionated radiotherapy of malignancies in the abdomen induces nausea and vomiting in approximately 50% of the patients. During abdominal irradiation the damaged gastrointestinal mucosa releases 5-HT with ensuing activation of 5-HT3 receptors which may explain the nausea and vomiting. Ondansetron is a new 5-HT3-antagonist with antiemetic properties. In this consecutive study, 33 patients receiving fractionated upper abdominal irradiation (greater-than-or-equal-to 100 cm2, 1,8-4 Gv daily dose for a mean of 13 days) were treated with ondansetron (8 mg t.d.s. p.o.). Emesis was completely controlled in 26/33 (79%) patients throughout their radiation course, which embraced 628 (94%) treatment days. Ondansetron was well tolerated. Eleven patients developed mild constipation. No patients experienced diarrhoea (a common distressing side-effect of abdominal irradiation). It is suggested that ondansetron can be of value in preventing emesis in patients receiving fractionated radiotherapy. The possible beneficial effect in preventing diarrhoea must be further evaluated.
引用
收藏
页码:767 / 769
页数:3
相关论文
共 14 条
  • [1] CLINICAL-EVALUATION OF 5-HT3 RECEPTOR ANTAGONISTS AS ANTIEMETICS
    BUNCE, K
    TYERS, M
    BERANEK, P
    [J]. TRENDS IN PHARMACOLOGICAL SCIENCES, 1991, 12 (02) : 46 - 48
  • [2] PHARMACOLOGICAL PROPERTIES OF GR38032F, A NOVEL ANTAGONIST AT 5-HT3 RECEPTORS
    BUTLER, A
    HILL, JM
    IRELAND, SJ
    JORDAN, CC
    TYERS, MB
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1988, 94 (02) : 397 - 412
  • [3] ACUTE RADIATION SYNDROME - MEMORIAL TO COURTBROWN,WILLIAM,MICHAEL
    DANJOUX, CE
    RIDER, WD
    FITZPATRICK, PJ
    [J]. CLINICAL RADIOLOGY, 1979, 30 (05) : 581 - 584
  • [4] GORE S, 1990, ALIMENT PHARM THERAP, V4, P139
  • [5] GRALLA R, 1988, CLINICIAN, V6, P26
  • [6] Gunning SJ, 1987, BRIT J PHARMACOL, V90, P135
  • [7] HENRIKSSON R, 1991, AM J MED S217, V91, P151
  • [8] RANDOMIZED CLINICAL-TRIAL OF LEVONANTRADOL AND CHLORPROMAZINE IN THE PREVENTION OF RADIOTHERAPY-INDUCED VOMITING
    LUCRAFT, HH
    PALMER, MK
    [J]. CLINICAL RADIOLOGY, 1982, 33 (06) : 621 - 622
  • [9] A DOUBLE-BLIND RANDOMIZED CROSSOVER COMPARISON OF NABILONE AND METOCLOPRAMIDE IN THE CONTROL OF RADIATION-INDUCED NAUSEA
    PRIESTMAN, SG
    PRIESTMAN, TJ
    CANNEY, PA
    [J]. CLINICAL RADIOLOGY, 1987, 38 (05) : 543 - 544
  • [10] Priestman T J, 1990, Clin Oncol (R Coll Radiol), V2, P71, DOI 10.1016/S0936-6555(05)80790-3