GAS-CHROMATOGRAPHY MASS-SPECTROMETRIC ANALYSIS OF URINARY NUCLEOSIDES IN CANCER-PATIENTS - POTENTIAL OF MODIFIED NUCLEOSIDES AS TUMOR-MARKERS

被引：41

作者：

LANGRIDGE, JI

MCCLURE, TD

ELSHAKAWI, S

FIELDING, A

SCHRAM, KH

NEWTON, RP

机构：

[1] UNIV COLL SWANSEA, BIOCHEM RES GRP SOBS, SWANSEA SA2 8PP, W GLAM, WALES

[2] UNIV COLL SWANSEA, MASS SPECTROMETRY RES UNIT, SWANSEA SA2 8PP, W GLAM, WALES

[3] UNIV ARIZONA, ARIZONA HLTH SCI CTR, COLL PHARMACOL, TUCSON, AZ 85724 USA

[4] SINGLETON HOSP, ONCOL UNIT, SWANSEA, WALES

[5] SINGLETON HOSP, CHEM PATHOL UNIT, SWANSEA, WALES

来源：

RAPID COMMUNICATIONS IN MASS SPECTROMETRY | 1993年 / 7卷 / 06期

关键词：

D O I：

10.1002/rcm.1290070605

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Analysis of urine from cancer patients by capillary gas chromatography/mass spectrometry positively identified 14 urinary nucleosides including several modified nucleosides. Levels of the modified nucleosides 1-methyladenosine, 2-methylguanosine, N2,N2-dimethylguanosine and 1-methylinosine as well as the total nucleoside level were elevated in the urine when a malignant tumour was present; the levels of N2,N2-dimethylguanosine were found to correlate with the stage of the cancer.

引用

页码：427 / 434

页数：8

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