STEREOSPECIFIC SYNTHESIS OF N-[BIS(METHYLTHIO)METHYLENE]-ALPHA,BETA-DIDEHYDROAMINO ACID METHYL-ESTERS, NEW SYNTHONS IN THE SYNTHESIS OF ALPHA-AMINO-ACIDS

被引：13

作者：

CATIVIELA, C

DEVILLEGAS, MDD

机构：

[1] Instituto de Ciencia de Materiales, Aragón. Departamento de Química Orgánica, Universidad de Zaragoza-C.S.I.C.

来源：

TETRAHEDRON | 1993年 / 49卷 / 02期

关键词：

STEREOSPECIFIC DEHYDRATION; STEREOISOMERS; DIDEHYDROAMINO ACIDS; AMINO ACIDS; E-Z ISOMERIZATION;

D O I：

10.1016/S0040-4020(01)80317-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

N-[Bis(methylthio)methylene]-alpha,beta-didehydroamino acid methyl esters 4a-c have been prepared with total geometric selectivity from easily accesible beta-hydroxyamino acids through N-[bis(methylthio)methylene]-beta-hydroxyamino acid methyl esters 3a-c as intermediates. The (E)-isomers can be easily converted into the corresponding (Z)-isomers in the presence of a catalytic amount of titanium (IV) chloride.

引用

页码：497 / 506

页数：10

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