ANTITUMOR-ACTIVITY OF ENTEROCOCCUS-FAECALIS FK-23 PREPARATION AGAINST MURINE SYNGENEIC TUMORS

被引：5

作者：

OHASI, K

SATONAKA, K

YAMAMOTO, T

YAMAZAKI, M

KIMURA, S

ABE, S

YAMAGUCHI, H

机构：

[1] TEIKYO UNIV, FAC PHARMACEUT SCI, SAGAMIKO, KANAGAWA 19901, JAPAN

[2] TEIKYO UNIV, SCH MED, TOKYO 173, JAPAN

来源：

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN | 1993年 / 113卷 / 05期

关键词：

ENTEROCOCCUS-FAECALIS; FK-23; MM46; TUMOR; ANTITUMOR ACTIVITY; TNF;

D O I：

10.1248/yakushi1947.113.5_396

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The antitumor activity of a preparation of heat-killed cells of Enterococcus faecalis, FK-23. Intraperitoneal injection of the preparation prolonged the lifespan of C3H/He N mice which were intraperitoneally inoculated with MM46 mammary carcinoma. Not only intraperitoneal but also oral administration of the FK-23 preparation inhibited the growth of these carcinomas inoculated intradermally. The tumor-bearing mice produced tumor necrosis factor (TNF) in their sera 2 h after intravenous injection of OK432. This TNF level increased after the mice were fed with food supplemented with the FK-23 preparation. Additionally, the FK-23 preparation inhibited the growth of Meth A fibrosarcoma in cyclophosphamide-treated BALB/c mice.

引用

页码：396 / 399

页数：4