A SYSTEMATIC STUDY ON THE CHEMICAL-STABILITY OF THE NOVEL INDOLOQUINONE ANTITUMOR AGENT EO9

被引：14

作者：

DEVRIES, JD

WINKELHORST, J

UNDERBERG, WJM

HENRAR, REC

BEIJNEN, JH

机构：

[1] UNIV UTRECHT,FAC PHARM,DEPT PHARMACEUT ANAL,3584 CA UTRECHT,NETHERLANDS

[2] FREE UNIV AMSTERDAM HOSP,NDDO,EORTC,1081 HV AMSTERDAM,NETHERLANDS

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1993年 / 100卷 / 1-3期

关键词：

EO9; CHEMICAL STABILITY; DEGRADATION KINETICS;

D O I：

10.1016/0378-5173(93)90089-X

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The chemical stability of the new anticancer drug EO9 in aqueous solution has been investigated utilizing a stability-indicating reversed-phase high-performance liquid chromatographic assay with ultraviolet detection and ultraviolet spectrophotometry. The degradation kinetics of EO9 have been studied as a function of pH, buffer composition, ionic strength and temperature. A pH-rate profile, using rate constants extrapolated to zero buffer concentration, was constructed demonstrating that EO9 is most stable in the pH region 8-9. The degradation mechanism of EO9 in aqueous solution is discussed.

引用

页码：181 / 188

页数：8

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