PEPTIDERGIC NEURONS OF SUBCORTICAL WHITE-MATTER IN AGING AND ALZHEIMERS BRAIN

被引：24

作者：

ANG, LC

SHUL, DD

机构：

[1] UNIV SASKATCHEWAN,DEPT PATHOL,SASKATOON,SK S7N 0W0,CANADA

[2] UNIV SASKATCHEWAN,ROYAL UNIV HOSP,SASKATOON,SK S7N 0W0,CANADA

来源：

BRAIN RESEARCH | 1995年 / 674卷 / 02期

关键词：

INTERSTITIAL NEURON; SUBPLATE NEURON; SOMATOSTATIN; NEUROPEPTIDE Y; SUBSTANCE P; CHOLECYSTOKININ;

D O I：

10.1016/0006-8993(95)00034-N

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Most of the neurons in the subcortical white matter of the adult cerebrum are remnants of the transient subplate cortex which appears during early cortical development. The peptidergic neurons in the subcortical white matter beneath the striate cortex were examined qualitatively and quantitatively with immunohistochemistry for substance P, cholecystokinin, somatostatin and neuropeptide Y in seven control patients and eight patients with Alzheimer's disease. The different peptidergic subcortical neurons still persisted in normal aging. In Alzheimer's disease, however, the substance P- and somatostatin-immunoreactive neurons were decreased in numbers and showed degenerative changes.

引用

页码：329 / 335

页数：7

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