VACCINATION WITH WHOLE-CELL VACCINE AND BACTERIAL PROTEIN EXTRACT PROTECTS TILAPIA AGAINST STREPTOCOCCUS DIFFICILE MENINGOENCEPHALITIS

被引：38

作者：

ELDAR, A

SHAPIRO, O

BEJERANO, Y

BERCOVIER, H

机构：

[1] HEBREW UNIV JERUSALEM,HADASSAH MED SCH,DEPT CLIN MICROBIOL,IL-91120 JERUSALEM,ISRAEL

[2] NIR DAVID LAB FISH DIS,NIR DAVID,ISRAEL

来源：

VACCINE | 1995年 / 13卷 / 09期

关键词：

STREPTOCOCCUS DIFFICILE; FISH MENINGOENCEPHALITIS; WHOLE-CELL VACCINE; ANTIBODIES; TILAPIA;

D O I：

10.1016/0264-410X(94)00067-W

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Formalin-killed Streptococcus difficile strains used as vaccines delivered intraperitoneally were able to protect tilapia against a challenge of 100 LD(50). The protection obtained was not strain specific. A vaccine based on an S. difficile extract containing 50% protein conjugated to alum also protected tilapia challenged with a virulent S. difficile strain. Protection in tilapia was correlated with the development of specific agglutinins. Western blot analysis supported the hypothesis that only a few proteins act as protective antigens in both the whole-cell vaccine and the streptococcal extract. The high efficacy of these vaccines make them good candidates for the control of streptococcal fish meningoencephalitis.

引用

页码：867 / 870

页数：4

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