STUDIES ON THE METABOLIC ROLE OF PEPTIDYL-TRANSFER RNA HYDROLASE .5. ACCUMULATION OF PEPTIDYL TRANSFER-RNA IS LETHAL TO ESCHERICHIA-COLI

被引：84

作者：

MENNINGER, JR ^{[1
]}

机构：

[1] UNIV IOWA, DEPT ZOOL, IOWA CITY, IA 52242 USA

来源：

JOURNAL OF BACTERIOLOGY | 1979年 / 137卷 / 01期

关键词：

D O I：

10.1128/JB.137.1.694-696.1979

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

A mutant strain of E. coli with temperature-sensitive peptidyl-tRNA hydrolase grows at 30.degree. C but, when shifted to 40.degree. C, dies at rates affected by physiological, pharmacological and genetical perturbations. The rate of killing correlates with the relative accumulation of peptidyl-tRNA, suggesting that it is responsible for the death of the cells.

引用

页码：694 / 696

页数：3

共 5 条

[1] MUTANT ESCHERICHIA-COLI STRAIN WITH TEMPERATURE SENSITIVE PEPTIDYL-TRANSFER RNA HYDROLASE [J].