ANTIMICROBIAL SUSCEPTIBILITY OF SALMONELLA-TYPHIMURIUM CARRYING THE OUTER-MEMBRANE PERMEABILITY MUTATION SS-B

被引:22
作者
VAARA, M [1 ]
机构
[1] UNIV CALIF BERKELEY,DEPT MICROBIOL & IMMUNOL,BERKELEY,CA 94720
关键词
D O I
10.1128/AAC.34.5.853
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The antibiotic susceptibility profile of Salmonella typhimurium SS-B, a mutant susceptible to some antimicrobial agents, was studied in detail. Twenty-eight agents were tested, and eleven of these had MICs significantly lower (32- to > 250-fold) for the SS-B strain than for its parent. The drugs were generally hydrophobic or amphiphilic. Polymyxin B nonapeptide, which has a known outer membrane permeabilizing action, further reduced the MIC of several of these agents of these agents for the SS-B strain by a factor of approximately 10 to 30. In most cases, the resulting MICs were lower than the corresponding MICs for the parent strain grown in the presence of polymyxin B nonapeptide. In addition, the hydrophobic fluorescent probe N-phenyl naphthylamine was rapidly embedded in the membranes of the SS-B strain but was poorly embedded in those of the parent strain.
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页码:853 / 857
页数:5
相关论文
共 41 条
[1]  
ALLEN NE, 1985, ANNU REP MED CHEM, V20, P155
[2]  
ATKINSON BA, 1986, ANTIBIOTICS LABORATO, P995
[3]   PERMEATION OF HYDROPHILIC MOLECULES THROUGH THE OUTER-MEMBRANE OF GRAM-NEGATIVE BACTERIA - REVIEW ON BACTERIAL PORINS [J].
BENZ, R ;
BAUER, K .
EUROPEAN JOURNAL OF BIOCHEMISTRY, 1988, 176 (01) :1-19
[4]  
CLARK D, 1984, FEMS MICROBIOL LETT, V21, P189
[5]   2 MUTATIONS WHICH AFFECT THE BARRIER FUNCTION OF THE ESCHERICHIA-COLI K-12 OUTER-MEMBRANE [J].
COLEMAN, WG ;
LEIVE, L .
JOURNAL OF BACTERIOLOGY, 1979, 139 (03) :899-910
[6]   AFFINITIES OF PENICILLINS AND CEPHALOSPORINS FOR THE PENICILLIN-BINDING PROTEINS OF ESCHERICHIA-COLI K-12 AND THEIR ANTIBACTERIAL ACTIVITY [J].
CURTIS, NAC ;
ORR, D ;
ROSS, GW ;
BOULTON, MG .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1979, 16 (05) :533-539
[7]  
GRUNDSTROM T, 1980, J BACTERIOL, V144, P844
[8]   OUTER PENETRATION BARRIER OF ESCHERICHIA-COLI K-12 - KINETICS OF UPTAKE OF GENTIAN VIOLET BY WILD-TYPE AND ENVELOPE MUTANTS [J].
GUSTAFSS.P ;
NORDSTRO.K ;
NORMARK, S .
JOURNAL OF BACTERIOLOGY, 1973, 116 (02) :893-900
[9]  
Hancock R E, 1985, Antibiot Chemother (1971), V36, P95
[10]   COMPOUNDS WHICH INCREASE THE PERMEABILITY OF THE PSEUDOMONAS-AERUGINOSA OUTER-MEMBRANE [J].
HANCOCK, REW ;
WONG, PGW .
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1984, 26 (01) :48-52