9-[2-(PHOSPHONOMETHOXY)ALKOXY]PURINES, A NEW SERIES OF ANTIVIRAL ACYCLONUCLEOTIDES

被引：14

作者：

DUCKWORTH, DM

HARNDEN, MR

PERKINS, RM

PLANTEROSE, DN

机构：

[1] SmithKline Beecham Pharmaceuticals, Biosciences Research Centre, Epsom, Surrey KT18 5XQ, Great Burgh

来源：

NUCLEOSIDES & NUCLEOTIDES | 1991年 / 10卷 / 1-3期

关键词：

D O I：

10.1080/07328319108046495

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis and antiviral activities of a series of 9-[2-(phosphonomethoxy)alkoxy]purines are described. These compounds are the first reported acyclonucleotides in which a phosphonic acid bearing moiety is attached to N-9 of a purine via an N-O bond. Some of them show potent activity against herpesviruses and others are potent and selective inhibitors of the replication of visna virus, a lentivirus.

引用

页码：427 / 430

页数：4

共 5 条

[1] A NOVEL SELECTIVE BROAD-SPECTRUM ANTI-DNA VIRUS AGENT [J].