EFFECT OF MOTILIN ON GASTRIC-EMPTYING IN PATIENTS WITH DIABETIC GASTROPARESIS

被引:31
作者
SCHMID, R
SCHUSDZIARRA, V
ALLESCHER, HD
BOFILIAS, I
BUTTERMANN, G
CLASSEN, M
机构
[1] TECH UNIV MUNICH, DEPT INTERNAL MED 2, ISMANINGER STR 22, W-8000 MUNICH 80, GERMANY
[2] TECH UNIV MUNICH, DEPT DIABET & DIETET, W-8000 MUNICH 80, GERMANY
关键词
D O I
10.2337/diacare.14.1.65
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Objectives: Because disturbances of gastric emptying are a serious complications in insulin-dependent diabetic subjects with regard to the maintenance of good metabolic control, we wanted to assess the effectiveness of motilin as a potential treatment for gastric emptying disturbances. Research Design and Methods: The intestinal hormone motilin has been shown to accelerate gastric emptying in healthy subjects. Therefore, we examined the effect of intravenous motilin on gastric emptying of a Tc-99m colloid-labeled semisolid test meal in 9 insulin-dependent diabetic patients with diabetic gastroparesis. All patients had a significantly delayed gastric emptying rate compared with a group of 11 healthy control subjects. Results: During the infusion of motilin, gastric emptying was accelerated, and it was no longer significantly different from control values. Conclusions: These data demonstrate that motilin and related compounds such as erythromycin derivatives could be useful for the treatment of disturbed gastric emptying in diabetic subjects.
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页码:65 / 68
页数:4
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