THE DEGRADATION OF CARBOPLATIN IN AQUEOUS-SOLUTIONS CONTAINING CHLORIDE OR OTHER SELECTED NUCLEOPHILES

被引：36

作者：

ALLSOPP, MA

SEWELL, GJ

ROWLAND, CG

RILEY, CM

SCHOWEN, RL

机构：

[1] UNIV EXETER,POSTGRAD MED SCH,BARRACK RD,EXETER EX2 5DW,ENGLAND

[2] UNIV KANSAS,DEPT PHARMACEUT CHEM,LAWRENCE,KS 66045

[3] UNIV KANSAS,DEPT CHEM,LAWRENCE,KS 66045

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1991年 / 69卷 / 03期

关键词：

PLATINUM(II) COMPLEX; CARBOPLATIN; CISPLATIN; DEGRADATION; KINETICS; REACTION MECHANISM; PH EFFECT; CHLORIDE EFFECT; TEMPERATURE EFFECT; NUCLEOPHILIC SUBSTITUTION;

D O I：

10.1016/0378-5173(91)90362-R

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The degradation kinetics of carboplatin in aqueous solution in the presence and absence of chloride ions were studied at elevated temperatures (43-70-degrees-C) at pH 7.0 and at various pH values at 70-degrees-C. Reaction rates were then extrapolated to temperatures of interest (infusion storage temperature, 'in-use' infusion temperature and body temperature) from Arrhenius plots. Additionally, the effects of pH and added chloride, thiosulphate, thiocyanate, azide and iodide on the rate of degradation of carboplatin were determined in an attempt to obtain a greater insight into the mechanism of nucleophilic substitution of carboplatin.

引用

页码：197 / 210

页数：14

共 11 条

[1] NUCLEOPHILIC CONSTANTS AND SUBSTRATE DISCRIMINATION FACTORS FOR SUBSTITUTION REACTIONS OF PLATINUM(2) COMPLEXES [J].