LIFETIME OF NEUTRAL-CARRIER-BASED LIQUID MEMBRANES IN AQUEOUS SAMPLES AND BLOOD AND THE LIPOPHILICITY OF MEMBRANE-COMPONENTS

被引：235

作者：

DINTEN, O ^{[1
]}

SPICHIGER, UE ^{[1
]}

CHANIOTAKIS, N ^{[1
]}

GEHRIG, P ^{[1
]}

RUSTERHOLZ, B ^{[1
]}

MORF, WE ^{[1
]}

SIMON, W ^{[1
]}

机构：

[1] SWISS FED INST TECHNOL,SWISS FED INST TECHNOL,DEPT ORGAN CHEM,UNIV STR 16,CH-8092 ZURICH,SWITZERLAND

来源：

ANALYTICAL CHEMISTRY | 1991年 / 63卷 / 06期

关键词：

D O I：

10.1021/ac00006a009

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

On the basis of previously reported correlations between the lipophilicity of membrane components, their partition coefficient between the membrane and the sample, and the lifetime of corresponding neutral-carrier-based sensors, the lipophilicities of ionophores and plasticizers in analytically relevant ion-selective electrodes, ISFETs, and optodes are analyzed and reported. Equations for the estimation of the lifetimes of liquid membranes in continuous-flow systems are presented, and the experimental determination of the lipophilicity values by thin-layer chromatography (TLC) is described. The required lipophilicities for the lifetimes of liquid membranes over 30 24-h days for different applications in aqueous solutions as well as in blood are presented. A comparison of the experimental results of lifetime measurements with calculated theoretical values is given. The experimental results of the determination of the lipophilicity by TLC are compared with the lipophilicities estimated on the basis of Hansch parameters.

引用

页码：596 / 603

页数：8

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