THERAPEUTIC EFFECT OF SODIUM DICHLOROACETATE ON VISUAL AND AUDITORY HALLUCINATIONS IN A PATIENT WITH MELAS

被引:34
作者
SAIJO, T
NAITO, E
ITO, M
TAKEDA, E
HASHIMOTO, T
KURODA, Y
机构
关键词
MITOCHONDRIAL MYOPATHY; ENCEPHALOPATHY; LACTIC ACIDOSIS; AND STROKE-LIKE; EPISODES; SODIUM DICHLOROACETATE; LACTATE; HALLUCINATION;
D O I
10.1055/s-2008-1071436
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
We report a patient with mitochondrial myopathy, encephalopathy, lactic acidosis, and strokelike episodes who experienced visual and auditory hallucinations. His blood and cerebrospinal fluid lactate levels were remarkably elevated. Sodium dichloroacetate was administered orally at doses of 12.5 to 100 mg/kg/day. On normalization of the lactate levels, the hallucinations disappeared.
引用
收藏
页码:166 / 167
页数:2
相关论文
共 8 条
[1]   RESPONSE TO LACTATE INFUSION IN GENERALIZED ANXIETY DISORDER [J].
COWLEY, DS ;
DAGER, SR ;
MCCLELLAN, J ;
ROYBYRNE, PP ;
DUNNER, DL .
BIOLOGICAL PSYCHIATRY, 1988, 24 (04) :409-414
[2]   MITOCHONDRIAL MYOPATHIES [J].
DIMAURO, S ;
BONILLA, E ;
ZEVIANI, M ;
NAKAGAWA, M ;
DEVIVO, DC .
ANNALS OF NEUROLOGY, 1985, 17 (06) :521-538
[3]   TREATMENT OF CHRONIC CONGENITAL LACTIC-ACIDOSIS BY ORAL-ADMINISTRATION OF DICHLOROACETATE [J].
KURODA, Y ;
ITO, M ;
TOSHIMA, K ;
TAKEDA, E ;
NAITO, E ;
HWANG, TJ ;
HASHIMOTO, T ;
MIYAO, M ;
MASUDA, M ;
YAMASHITA, K ;
ADACHI, T ;
SUZUKI, Y ;
NISHIYAMA, K .
JOURNAL OF INHERITED METABOLIC DISEASE, 1986, 9 (03) :244-252
[4]   HYPERALANINEMIA, HYPERPYRUVICEMIA AND LACTIC-ACIDOSIS DUE TO PYRUVATE-CARBOXYLASE DEFICIENCY OF LIVER - TREATMENT WITH THIAMINE AND LIPOIC ACID [J].
MAESAKA, H ;
KOMIYA, K ;
MISUGI, K ;
TADA, K .
EUROPEAN JOURNAL OF PEDIATRICS, 1976, 122 (02) :159-168
[5]   MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC-ACIDOSIS, AND STROKELIKE EPISODES - A DISTINCTIVE CLINICAL SYNDROME [J].
PAVLAKIS, SG ;
PHILLIPS, PC ;
DIMAURO, S ;
DEVIVO, DC ;
ROWLAND, LP .
ANNALS OF NEUROLOGY, 1984, 16 (04) :481-488
[6]   THE PHARMACOLOGY OF DICHLOROACETATE [J].
STACPOOLE, PW .
METABOLISM-CLINICAL AND EXPERIMENTAL, 1989, 38 (11) :1124-1144
[7]   ENZYMOLOGIC STUDIES AND THERAPY OF LEIGHS DISEASE ASSOCIATED WITH PYRUVATE DECARBOXYLASE DEFICIENCY [J].
TOSHIMA, K ;
KURODA, Y ;
HASHIMOTO, T ;
ITO, M ;
WATANABE, T ;
MIYAO, M ;
II, K .
PEDIATRIC RESEARCH, 1982, 16 (06) :430-435
[8]   MITOCHONDRIAL MYOPATHY, ENCEPHALOPATHY, LACTIC-ACIDOSIS, AND STROKELIKE EPISODES WITH RECURRENT ABDOMINAL SYMPTOMS AND COENZYME-Q10 ADMINISTRATION [J].
YAMAMOTO, M ;
SATO, T ;
ANNO, M ;
UJIKE, H ;
TAKEMOTO, M .
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY, 1987, 50 (11) :1475-1481