CA2+ CHANNEL BLOCKING EFFECTS OF HIRSUTINE, AN INDOLE ALKALOID FROM UNCARIA GENUS, IN THE ISOLATED RAT AORTA

被引：53

作者：

YANO, S ^{[1
]}

HORIUCHI, H ^{[1
]}

HORIE, S ^{[1
]}

AIMI, N ^{[1
]}

SAKAI, S ^{[1
]}

WATANABE, K ^{[1
]}

机构：

[1] CHIBA UNIV, FAC PHARMACEUT SCI, DEPT MED MAT, CHIBA 260, JAPAN

来源：

PLANTA MEDICA | 1991年 / 57卷 / 05期

关键词：

HIRSUTINE; UNCARIA GENUS; VASODILATATION; CALCIUM CHANNEL BLOCKER; AORTA;

D O I：

10.1055/s-2006-960134

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ca2+ channel blocking activity of hirsutine and its pharmacological features were studied. Hirsutine (10(-6) to 3 x 10(-5) M) produced a dose-dependent relaxation of the isolated rat aorta contracted by norepinephrine and high K+ concentration. This effect was exhibited in the aorta strips with or without the endothelium, suggesting an involvement of vasodilative mechanisms not dependent on the endothelium. Hirsutine also inhibited the contractions induced by serotonin and Ca2+ channel activator YC-170, but not by Ca2+ ionophore A23187. The pA2 value of hirsutine was 6.6 +/- 0.1 (mean +/- S.E.; n = 4) in antagonizing cumulative dose-response curve for Ca2+ in the depolarized aorta strips. It is concluded that hirsutine apparently exhibits Ca2+ channel blocking activity mainly through inhibition of the voltage-dependent Ca2+ influx.

引用

页码：403 / 405

页数：3

共 17 条

[1]

AIMI N, 1977, CHEM PHARM BULL, V25, P2067

[2]

AIMI N, 1987, J TRADITIONAL SINO J, V8, P53

[3] HYPOTENSIVE ACTION OF 3-ALPHA-DIHYDROCADAMBINE, AN INDOLE ALKALOID GLYCOSIDE OF UNCARIA HOOKS .90. [J].

AISAKA, K ;

HATTORI, Y ;

KIHARA, T ;

ISHIHARA, T ;

ENDO, K ;

HIKINO, H .

PLANTA MEDICA, 1985, 51 (05) :424-427

[4] VALIDITY OF THE ORIENTAL MEDICINES .50. HYPOTENSIVE PRINCIPLES OF UNCARIA HOOKS [J].

ENDO, K ;

OSHIMA, Y ;

KIKUCHI, H ;

KOSHIHARA, Y ;

HIKINO, H .

PLANTA MEDICA, 1983, 49 (03) :188-190

[5] THE OBLIGATORY ROLE OF ENDOTHELIAL-CELLS IN THE RELAXATION OF ARTERIAL SMOOTH-MUSCLE BY ACETYLCHOLINE [J].

FURCHGOTT, RF ;

ZAWADZKI, JV .

NATURE, 1980, 288 (5789) :373-376

[6] PLANTS CONTAINING INDOLE ALKALOIDS .1. ALKALOIDS IN UNCARIA-GENUS [J].

HAGINIWA, J ;

SAKAI, SI ;

TAKAHASHI, K .

YAKUGAKU ZASSHI, 1971, 91 (05) :575-+

[7] STUDIES OF PLANTS CONTAINING INDOLE ALKALOIDS .2. ALKALOIDS OF UNCARIA-RHYNCHOPHYLLA MIQ [J].

HAGINIWA, J ;

SAKAI, S ;

AIMI, N ;

YAMANAKA, E ;

SHINMA, N .

YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN, 1973, 93 (04) :448-452

[8]

HARADA M, 1974, CHEM PHARM BULL, V22, P1372

[9]

HATTORI Y, 1986, J PHARMACOL EXP THER, V238, P670

[10]

ITO Y, 1990, CHEM PHARM BULL, V38, P1702

← 1 2 →