A VERSATILE STRATEGY FOR THE DERIVATIZATION OF THE CARBOXY GROUP OF AMPHOTERICIN-B - THE PREPARATION OF C-16 KETONE ANALOGS

被引：9

作者：

DRIVER, MJ ^{[1
]}

GREENLEES, AR ^{[1
]}

MACPHERSON, DT ^{[1
]}

机构：

[1] SMITHKLINE BEECHAM PHARMACEUT,YEW TREE BOTTOM RD,EPSOM KT18 5XQ,SURREY,ENGLAND

来源：

JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1 | 1992年 / 23期

关键词：

D O I：

10.1039/p19920003155

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The carboxy group of amphotericin B 1 has been converted into a range of ketone analogues 12-15 via a strategy based on the use of protecting groups to facilitate derivatisation of 1.

引用

页码：3155 / 3157

页数：3

共 18 条

[1]

ABIKO A, 1988, TETRAHEDRON LETT, P447

[2] CONVENIENT METHOD FOR PREPARATION OF KETONES BY REACTION OF GRIGNARD-REAGENTS WITH CARBOXYLIC-ACID DERIVATIVES [J].

ARAKI, M ;

SAKATA, S ;

TAKEI, H ;

MUKAIYAM.T .

BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN, 1974, 47 (07) :1777-1780

[3]

ARAKI M, 1973, J AM CHEM SOC, V95, P4763

[4]

BOROWSKI E, 1988, BIOCHEM PHARMACOL, V37, P827

[5]

BOROWSKI E, 1991, J ANTIBIOT, V44, P979

[6] AMPHOTERICIN-B - DELIVERY SYSTEMS [J].

BRAJTBURG, J ;

POWDERLY, WG ;

KOBAYASHI, GS ;

MEDOFF, G .

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 1990, 34 (03) :381-384

[7]

CHAKRABORTY TK, 1988, J AM CHEM SOC, V110, P4660

[8]

CHAKRABORTY TK, 1988, J AM CHEM SOC, V110, P4696

[9]

CLAREMAN DA, 1981, TETRAHEDRON LETT, P4647

[10]

CLARK DA, 1979, TETRAHEDRON LETT, P2875

← 1 2 →