FETAL HYPERECHOGENIC BOWEL AND DOWNS-SYNDROME

被引:24
作者
NYBERG, DA
RESTA, RG
MAHONY, BS
DUBINSKY, T
LUTHY, DA
HICKOK, DE
LUTHARDT, FW
机构
[1] Center for Perinatal Studies, Swedish Hospital Medical Center, Seattle, Washington
关键词
FETUS ABNORMALITIES; CHROMOSOME ABNORMALITIES; PRENATAL ULTRASONOGRAPHY; PRENATAL DIAGNOSIS; DOWNS SYNDROME; BOWEL; MECONIUM;
D O I
10.1046/j.1469-0705.1993.03050330.x
中图分类号
O42 [声学];
学科分类号
070206 ; 082403 ;
摘要
Hyperechogenic bowel was identified among 55 of 6781 (0.81%) fetuses prior to second-trimester genetic amniocentesis. Trisomy 21 was found in eight of the 55 (14.5%) fetuses identified with hyperechogenic bowel compared to 60 of 6726 (0.89%) fetuses with normal bowel echogenicity (p < 0.001). Hyperechogenic bowel carried a 16-fold greater risk for Down's syndrome than normal bowel echogenicity (relative risk 16.8, 95%; confidence intervals 8.2-32.5). Chromosome abnormalities other than trisomy 21 were found in four additional fetuses with hyperechogenic bowel (two triploid and one each with 47,XXX; 45,X/47,XXX mosaicisim). Combining these four cases with the eight fetuses having trisomy 21, 21.8% (12 of 55) of fetuses with hyperechogenic bowel proved to have a chromosome abnormality. We conclude that hyperechogenic bowel is associated with chromosome abnormalities, particularly Down's syndrome, when detected during the second trimester.
引用
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页码:330 / 333
页数:4
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