HIGH-PERFORMANCE LIQUID-CHROMATOGRAPHIC DETERMINATION OF ACLACINOMYCIN-A AND ITS RELATED-COMPOUNDS .2. REVERSE PHASE HPLC DETERMINATION OF ACLACINOMYCIN-A AND ITS METABOLITES IN BIOLOGICAL-FLUIDS USING FLUORESCENCE DETECTION

被引:25
作者
OGASAWARA, T [1 ]
MASUDA, Y [1 ]
GOTO, S [1 ]
MORI, S [1 ]
OKI, T [1 ]
机构
[1] SANRAKU OCEAN CO LTD, CENT RES LABS, FUJISAWA, KANAGAWA 251, JAPAN
关键词
D O I
10.7164/antibiotics.34.52
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
A sensitive, simple and selective reverse phase high performance liquid chromatographic method was applied to the determination of aclacinomycin A (ACM) and its metabolites in plasma. The chromatography was performed on a microparticulate phenethyl derivative of silica using a mobile phase of acetonitrile-0.03 M ammonium formate buffer (pH 5.0), (50:50, vol/vol) and monitoring with fluorescence detector (excitation 435 nm-emission 505 nm). High reproducibility and linear calibration curves were obtained from 20-100 ng/ml of ACM and its metabolites in [dog] plasma by use of internal standard methods.
引用
收藏
页码:52 / 57
页数:6
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