THEORY OF ENZYMATIC REVERSE-PROTONATION CATALYSIS

被引：12

作者：

MOCK, WL

机构：

[1] Department of Chemistry, University of Illinois at Chicago, Chicago

来源：

BIOORGANIC CHEMISTRY | 1992年 / 20卷 / 04期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/0045-2068(92)90047-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Consideration of the requirements for realization of concurrent acid-base catalysis, together with the consequences of differential binding energy for enzyme-substrate complexes within kinetically equivalent protonation states, provides an indication of a general mechanism for promotion of substrate conversion at enzyme active sites. © 1992.

引用

页码：377 / 381

页数：5

共 10 条

[1]

Cleland W W, 1977, Adv Enzymol Relat Areas Mol Biol, V45, P273

[2] GENERAL ACID-BASE CATALYSIS OF COMPLEX REACTIONS IN WATER [J].