THE EVOLUTIONARY DYNAMICS OF REPETITIVE DNA IN EUKARYOTES

被引：1326

作者：

CHARLESWORTH, B

SNIEGOWSKI, P

STEPHAN, W

机构：

[1] MICHIGAN STATE UNIV, CTR MICROBIAL ECOL, E LANSING, MI 48824 USA

[2] UNIV MARYLAND, DEPT ZOOL, COLLEGE PK, MD 20742 USA

来源：

NATURE | 1994年 / 371卷 / 6494期

关键词：

D O I：

10.1038/371215a0

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Repetitive DNA sequences form a large portion of the genomes of eukaryotes. The 'selfish DNA' hypothesis proposes that they are maintained by their ability to replicate within the genome. The behaviour of repetitive sequences can result in mutations that cause genetic diseases, and confer significant fitness losses on the organism. Features of the organization of repetitive sequences in eukaryotic genomes, and their distribution in natural populations, reflect the evolutionary forces acting on selfish DNA.

引用

页码：215 / 220

页数：6

共 102 条

[1] Biology and applications of human minisatellite loci [J].