UV-B EXPOSURE IMPAIRS RESISTANCE TO INFECTION BY TRICHINELLA-SPIRALIS

被引:44
作者
GOETTSCH, W
GARSSEN, J
DEIJNS, A
DEGRUIJL, FR
VANLOVEREN, H
机构
[1] NATL INST PUBL HLTH & ENVIRONM PROTECT,3720 BA BILTHOVEN,NETHERLANDS
[2] UNIV UTRECHT,DEPT DERMATOL,UTRECHT,NETHERLANDS
关键词
ANTIBODIES; IMMUNOSUPPRESSION; INFECTIOUS DISEASES; OZONE LAYER; TRICHINELLA SPIRALIS; ULTRAVIOLET-B RADIATION;
D O I
10.1289/ehp.94102298
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
To assess the possibility that increases in UV-B exposure on the earth's surface could lead to impaired resistance to several infectious diseases, we studies the effect of UV-B exposure on resistance against Trichinella spiralis. Wistar rats, orally infected with T. spiralis larvae, were exposed to suberythemal doses of UV-B radiation daily for 5 days at different time periods before or after infection. A significant increase in the number of Trichinella larvae was found in the carcasses of rats irradiated with UV-B between 6 and 10 days after infection. These data indicate that exposure to UV-B radiation suppresses the resistance to a parasitic infection. We suggested that UV-B radiation especially suppresses cellular immune responses against these worms because specific IgM, IgG, and IgE titers were not significantly altered by UV-B exposure. These data indicate that UV-B irradiation plays a role in the course of infection with T. spiralis, which suggests that increases of UV-B exposure might also lead to problems with other infectious diseases and might affect vaccination because of the interaction of UV-B irradiation with memory T-cells.
引用
收藏
页码:298 / 301
页数:4
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