FAILURE TO TRANSFER MULTIPLE-SCLEROSIS INTO SEVERE COMBINED IMMUNODEFICIENCY MICE BY MONONUCLEAR-CELLS FROM CSF OF PATIENTS

被引：13

作者：

HAO, Q

SAIDA, T

NISHIMURA, M

OZAWA, K

SAIDA, K

机构：

[1] UTANO NATL HOSP,DEPT NEUROL,UKYO KU,KYOTO,KYOTO 616,JAPAN

[2] UTANO NATL HOSP,CLIN RES CTR,KYOTO,KYOTO,JAPAN

来源：

NEUROLOGY | 1994年 / 44卷 / 01期

关键词：

D O I：

10.1212/WNL.44.1.163

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

To confirm the reported transfer of multiple sclerosis (MS) by CSF cells, we injected CSF cells from six MS patients in the exacerbation stage into the cisterna magna of 18 severe combined immunodeficiency mice. No clinical neurologic abnormalities or light- or electron-microscopic pathologic changes were present in any transferred mice, and the reported results could not be reproduced.

引用

收藏

页码：163 / 165

页数：3

相关论文

共 5 条

[1] MS - A CNS AND SYSTEMIC AUTOIMMUNE-DISEASE [J].

HAFLER, DA ;

WEINER, HL .

IMMUNOLOGY TODAY, 1989, 10 (03) :104-107

[2] OBSERVATIONS ON THE EFFECT OF INJECTION OF LYMPHOCYTES FROM MULTIPLE-SCLEROSIS AND GUILLAIN-BARRE-SYNDROME IN THE RABBIT EYE MODEL [J].

KAMHANSEN, S ;

KRISTENSSON, K ;

LINK, H .

JOURNAL OF THE NEUROLOGICAL SCIENCES, 1979, 42 (02) :283-289

[3] NEW DIAGNOSTIC-CRITERIA FOR MULTIPLE-SCLEROSIS - GUIDELINES FOR RESEARCH PROTOCOLS [J].

POSER, CM ;

PATY, DW ;

SCHEINBERG, L ;

MCDONALD, WI ;

DAVIS, FA ;

EBERS, GC ;

JOHNSON, KP ;

SIBLEY, WA ;

SILBERBERG, DH ;

TOURTELLOTTE, WW .

ANNALS OF NEUROLOGY, 1983, 13 (03) :227-231

[4] TRANSFER OF MULTIPLE-SCLEROSIS INTO SEVERE COMBINED IMMUNODEFICIENCY MICE BY MONONUCLEAR-CELLS FROM CEREBROSPINAL-FLUID OF THE PATIENTS [J].

SAEKI, Y ;

MIMA, T ;

SAKODA, S ;

FUJIMURA, H ;

ARITA, N ;

NOMURA, T ;

KISHIMOTO, T .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (13) :6157-6161

[5] COMPARISON OF THE ANALGESIC EFFECTS OF VARIOUS OPIOID PEPTIDES BY A NEWLY DEVISED INTRACISTERNAL INJECTION TECHNIQUE IN CONSCIOUS MICE [J].

UEDA, H ;

AMANO, H ;

SHIOMI, H ;

TAKAGI, H .

EUROPEAN JOURNAL OF PHARMACOLOGY, 1979, 56 (03) :265-268