MONODISPERSE MAGNETIC POLYMER PARTICLES - NEW BIOCHEMICAL AND BIOMEDICAL APPLICATIONS

被引：104

作者：

UGELSTAD, J

STENSTAD, P

KILAAS, L

PRESTVIK, WS

HERJE, R

BERGE, A

HORNES, E

机构：

[1] UNIV TRONDHEIM,IND CHEM LAB,TRONDHEIM,NORWAY

[2] NORWEGIAN COLL VET MED,OSLO,NORWAY

[3] DYNAL AS,OSLO,NORWAY

来源：

BLOOD PURIFICATION | 1993年 / 11卷 / 06期

关键词：

MONODISPERSE PARTICLES; MAGNETIC PARTICLES; CELL SEPARATION; MICROBIOLOGY; MOLECULAR BIOLOGY;

D O I：

10.1159/000170129

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The method of activated swelling of polymer particles developed by the authors allows the preparation of monodisperse spherical beads of predictable size from 1 to 100 mu m in diameter. The polymer particles may be prepared from a number of different monomeric materials and with various morphologies including macroporous structures. The porous beads form the basis for magnetizable monodisperse polymer particles which have magnetic iron oxides distributed as small grains all through the volume of the beads. The magnetic particles are being used extensively for selective cell separation and for Cell separation immunomagnetic separation within microbiology and molecular biology. A review of recent work within these fields is given. New methods for positive cell separation are announced.

引用

页码：349 / 369

页数：21

共 67 条

[1]

Ugelstad J., Berge A., Ellingsen T., Schmid R., Nilsen T.N., Mork P.C., Stenstad P., Hornes E., Olsvik O., Preparation and application of new monosized polymer particles, Prog Polymer Sci, 17, pp. 87-161, (1992)

[2]

Ugelstad J., Mark P.C., Kaggerud K.H., Ellingsen T., Berge A., Swelling of oligomer-polymer particles. New methods of preparation of emulsions and polymer dispersions, Adv Colloid Interface Sci, 13, pp. 1201-1243, (1980)

[3]

Ugelstad J., Mork P.C., Mfutakamba H.R., Soleimany E., Nordhuus I., Schmid R., Berge A., Ellingsen T., Aune O., Nustad K., Thermodynamics of swelling of polymer, oligomer and polymer-oligomer particles. Preparation and application of monodisperse particles, Sci Technol Polymer Colloids, pp. 51-99, (1983)

[4]

Ugelstad J., Ellingsen T., Berge A., Helgee B., PCT Int Appl, (1983)

[5]

Ellingsen T., Aune O., Ugelstad J., Hagen S., Monosized stationary phases for chromatography, J Chromatogr, 535, pp. 147-161, (1990)

[6]

Ellingsen T., Aune O., Berge A., Kilaas L., Schmid R., Stenstad P., Ugelstad J., Hagen S., Weng E., Johansen L., Monosized polymer particles in biochemical and biomedical separations, Makromol Chem Macromol Symp, 70-71, pp. 315-326, (1993)

[7]

Lindmo T., Bormer O., Ugelstad J., Nustad K., Immunometric assay by flow cytometry using mixtures of two particle types of different affinity, J Immunol Methods, 126, pp. 183-189, (1990)

[8]

Frengen J., Schmid R., Kierulf B., Nustad K., Paus E., Berge A., Lindmo T., Homogeneous immunofluorometric assays for AFP based on macroprous, monosized particles and flow cytometry, Clin Chem

[9]

Frengen J., Kierulf B., Schmidt R., Lindmo T., Nustad K., Demonstration and elimination of serum interference in immunometric assays by means of flow cytometry, Clin Chem

[10]

Meakin P., Skjeltorp A.T., Application of experimental and numerical models for the physics of multiparticle systems, Adv Phys, 42, pp. 1-127, (1993)

← 1 2 3 4 5 6 7 →