MSD-PERFORMANCE, ECD-PERFORMANCE AND NPD-PERFORMANCE COMPARED IN THE ASSAY OF 6 NONSTEROIDAL ANTIINFLAMMATORY DRUGS IN PLASMA SAMPLES

被引:12
作者
GIACHETTI, C
ASSANDRI, A
ZANOLO, G
TENCONI, A
机构
[1] Istituto di Ricerche Biomediche 'A. Marxer', RBM S.p.A., Ivrea (To), 10015
关键词
GAS CHROMATOGRAPHY; MSD; ECD AND NPD; NONSTEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS); PLASMA SAMPLES;
D O I
10.1007/BF02274495
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
The aim of this work was to compare the performance of the MSD, ECD and NPD systems when used for drug assay in biological fluids. As a practical test, six non steroidal anti-inflammatory drugs added to plasma samples were detected and quantified. The analyses were carried out after solvent extraction from an acidic medium and subsequent methylation. The linearity of response was tested for all the detection systems in the range of 1 to 25 ng/ml. Precision and accuracy were determined at 1, 5 and 10 ng/ml. The minimum quantifiable level for the six drugs was about 1 ng/ml with each of the three detection systems.
引用
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页码:162 / 169
页数:8
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