IMMUNOLOGIC DEFENSES AGAINST METASTASES - IMPAIRMENT BY EXCISION OF AN ALLOTRANSPLANTED LYMPHOMA

被引：70

作者：

GERSHON, RK

CARTER, RL

KONDO, K

机构：

[1] Chester Beatty Research Institute, Institute of Cancer Research: Royal Cancer Hospital, London

来源：

SCIENCE | 1968年 / 159卷 / 3815期

关键词：

D O I：

10.1126/science.159.3815.646

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hamsters grafted with an allotransplantable lymphoma that does not metastasize develop a state of concomitant immunity which renders them refractory to reinoculation with cells of the same tumor. Removal of the tumor 7 days after transplantation rapidly leads to a decrease in immunity, the production of enhancing antibodies, and the appearance of metastatic deposits which are probably derived from preexisting tumor cells in the blood and lymphoid tissues.

引用

页码：646 / &

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