DISSOLUTION AND CRYSTAL GROWTH IN AQUEOUS SUSPENSIONS OF CORTISONE ACETATE

被引：27

作者：

CARLESS, JE

MOUSTAFA, MA

RAPSON, HDC

机构：

[1] Department of Pharmacy, Chelsea College of Science and Technology (University of London), London, SW3, Manresa Road

来源：

JOURNAL OF PHARMACY AND PHARMACOLOGY | 1968年 / 20卷 / 08期

关键词：

D O I：

10.1111/j.2042-7158.1968.tb09825.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The change in particle size distribution of cortisone acetate in aqueous (saline) suspensions has been examined using the Coulter Counter. Rate of growth under standardized conditions was calculated as increase of diameter per unit time. Solubility of a water‐unstable crystal form has been shown to be greater than that of the stable form. Discussion of the results reveals that crystal growth is mainly initiated by polymorphic transformation. Lattice energies, heats of wetting and solution of the different crystal forms are thought to be the rate controlling factors. 1968 Royal Pharmaceutical Society of Great Britain

引用

页码：630 / &

共 7 条

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