MECAMYLAMINE BLOCKADE OF NICOTINE ENHANCED NORADRENALINE TURNOVER IN RAT-BRAIN

被引：26

作者：

MORGAN, WW

PFEIL, KA

机构：

[1] Department of Anatomy The University, Texas Health Science Center at San Antonio, San Antonio, TX 78284

来源：

LIFE SCIENCES | 1979年 / 24卷 / 05期

关键词：

D O I：

10.1016/0024-3205(79)90212-1

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

The administration of nicotine significantly enhanced the depletion in noradrenaline (NA) observed in the brains of male Sprague-Dawley rats following alpha methyl-para-tyrosine (αMPT) administration. These data indicate that nicotine enhances the turnover of NA in the rat brain. This effect of nicotine was completely blocked by mecamylamine administration while mecamylamine alone had no observed effect on NA content or turnover. These data are consistent with the action of mecamylamine as an effective antagonist of the action of nicotine in the rat brain. © 1979.

引用

页码：417 / 420

页数：4

共 10 条

[1] EFFECT OF MECAMYLAMINE ON FATE OF DOPAMINE IN STRIATAL AND MESOLIMBIC AREAS OF RAT-BRAIN - INTERACTION WITH MORPHINE AND HALOPERIDOL [J].