SIGNIFICANT INCREASE OF 8-HYDROXYDEOXYGUANOSINE IN LIVER DNA OF RATS FOLLOWING SHORT-TERM EXPOSURE TO THE PEROXISOME PROLIFERATORS DI(2-ETHYLHEXYL)PHTHALATE AND DI(2-ETHYLHEXYL)ADIPATE

被引：86

作者：

TAKAGI, A

SAI, K

UMEMURA, T

HASEGAWA, R

KUROKAWA, Y

机构：

[1] Division of Toxicology, National Institute of Hygienic Sciences, Tokyo, 158, 1–18‐1, Kamiyoga, Setagaya‐ku

来源：

JAPANESE JOURNAL OF CANCER RESEARCH | 1990年 / 81卷 / 03期

关键词：

8‐Hydroxydeoxyguanosine; Di(2‐ethylhexyl)adipate; Di(2‐ethylhexyl)phthalate; DNA damage; Peroxisome proliferator;

D O I：

10.1111/j.1349-7006.1990.tb02551.x

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

8‐Hydroxydeoxyguanosine (8‐OH‐dG) levels were examined in liver and kidney DNA after di(2‐ethylhexyl)phthalate (DEHP), di(2‐ethylhexyl)adipate (DEHA) and phthalic anhydride administration to male 6‐week‐old F‐344 rats in the diet at concentrations of 1.2, 2.5 and 1.5%, respectively. Significant increases in 8‐OH‐dG levels were observed only in the liver (target organ of DEHP and DEHA carcinogenesis) DNA after 1 and 2 weeks of treatment with DEHP and DEHA, respectively. The results suggest the involvement of oxidative DNA damage in hepatocarcinogenesis by peroxisome proliferators. Copyright © 1990, Wiley Blackwell. All rights reserved

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页码：213 / 215

页数：3

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