LONG-TERM CHANGES INDUCED BY DEVELOPMENTAL HANDLING ON PAIN THRESHOLD - EFFECTS OF MORPHINE AND NALOXONE

被引：50

作者：

PIERETTI, S ^{[1
]}

DAMORE, A ^{[1
]}

LOIZZO, A ^{[1
]}

机构：

[1] IST SUPER SANITA,VIALE REGINA ELENA 299,I-00161 ROME,ITALY

来源：

BEHAVIORAL NEUROSCIENCE | 1991年 / 105卷 / 01期

关键词：

D O I：

10.1037/0735-7044.105.1.215

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Mice pups were exposed daily to a stress-producing procedure (handling and saline injection) during the first 3 weeks of life. At 25 and 45 days of age, they were tested for differences in the tail-flick and hot-plate tests. The results indicate that chronic handling procedures during developmental stages can produce a long-lasting increase of the threshold for painful stumuli. This phenomenon is completely prevented by naloxone pretreatment and has enchaning effects on morphine analgesia, thus suggesting that postnatal handling can exert long-lasting interference on the sensitivity of some opioid receptor populations.

引用

页码：215 / 218

页数：4

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