INHIBITION AND REACTIVATION OF CHICKEN KYNURENINE FORMAMIDASE - INVITRO STUDIES WITH ORGANOPHOSPHATES, N-ALKYLCARBAMATES, AND PHENYLMETHANESULFONYL FLUORIDE

被引：15

作者：

SEIFERT, J

CASIDA, JE

机构：

[1] Pesticide Chemistry and Toxicology Laboratory, Department of Entomological Sciences, University of California, Berkeley

来源：

PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY | 1979年 / 12卷 / 03期

关键词：

D O I：

10.1016/0048-3575(79)90112-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In studies on the mechanism of avian teratogenesis induced by organophosphorus and methylcarbamate insecticides, chicken liver kynurenine formamidase (KFase) was used as a convenient model for the more difficultly accessible but teratogenically relevant KFase of the yolk sac membrane. The parameters of in vitro KFase inhibition kinetics do not correlate with the teratogenic potency of various organophosphates and N-alkylcarbamates. The phosphorylated, carbamoylated, and sulfonylated enzymes are relatively resistant to reactivation of enzyme activity either spontaneously or by aldoximes or hydroxylamine. This refractory property may contribute to the prolonged in ovo KFase inhibition necessary for the NAD-deficiency type of teratogenesis. © 1979.

引用

页码：273 / 279

页数：7

共 21 条

[1]

ALDRIDGE WN, 1972, ENZYME INHIBITORS SU

[2]

BAILEY CB, 1974, J BIOL CHEM, V249, P4439

[3] MECHANISM OF IRREVERSIBLE ADRENERGIC BLOCKADE BY N-CARBETHOXYDIHYDROQUINOLINES - MODEL STUDIES WITH TYPICAL SERINE HYDROLASES [J].

BELLEAU, B ;

DITULLIO, V ;

GODIN, D .

BIOCHEMICAL PHARMACOLOGY, 1969, 18 (05) :1039-&

[4] GENETICS OF FORMAMIDASE-5 (BRAIN FORMAMIDASE) IN THE MOUSE - LOCALIZATION OF THE STRUCTURAL GENE ON CHROMOSOME-14 [J].

CUMMING, RB ;

WALTON, MF ;

FUSCOE, JC ;

TAYLOR, BA ;

WOMACK, JE ;

GAERTNER, FH .

BIOCHEMICAL GENETICS, 1979, 17 (5-6) :415-431

[5] A NEW AND RAPID COLORIMETRIC DETERMINATION OF ACETYLCHOLINESTERASE ACTIVITY [J].

ELLMAN, GL ;

COURTNEY, KD ;

ANDRES, V ;

FEATHERSTONE, RM .

BIOCHEMICAL PHARMACOLOGY, 1961, 7 (02) :88-&

[6] RELATIONSHIP OF ACYLATION OF MEMBRANE ESTERASES AND PROTEINS TO TERATOGENIC ACTION OF ORGANOPHOSPHORUS INSECTICIDES AND ESERINE IN DEVELOPING HEN EGGS [J].

FLOCKHART, IR ;

CASIDA, JE .

BIOCHEMICAL PHARMACOLOGY, 1972, 21 (19) :2591-+

[7] TRYPTOPHAN OXIDATION [J].

KNOX, WE .

METHODS IN ENZYMOLOGY, 1955, 2 :242-253

[8] SERINE PROTEASES - STRUCTURE AND MECHANISM OF CATALYSIS [J].

KRAUT, J .

ANNUAL REVIEW OF BIOCHEMISTRY, 1977, 46 :331-358

[9] AFFINITY + PHOSPHORYLATION CONSTANTS FOR INHIBITION OF ESTERASES BY ORGANOPHOSPHATES [J].

MAIN, AR .

SCIENCE, 1964, 144 (362) :992-+

[10] KYNURENINE FORMAMIDASE INHIBITION AS A POSSIBLE MECHANISM FOR CERTAIN TERATOGENIC EFFECTS OF ORGANOPHOSPHORUS AND METHYLCARBAMATE INSECTIDES IN CHICKEN EMBRYOS [J].

MOSCIONI, AD ;

ENGEL, JL ;

CASIDA, JE .

BIOCHEMICAL PHARMACOLOGY, 1977, 26 (23) :2251-2258

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