THE ROLE OF NONSTEROIDAL ANTIINFLAMMATORY DRUGS IN COLORECTAL-CANCER PREVENTION

被引：159

作者：

GIARDIELLO, FM

OFFERHAUS, GJA

DUBOIS, RN

机构：

[1] JOHNS HOPKINS UNIV, SCH MED, DEPT MED, BALTIMORE, MD 21205 USA

[2] VANDERBILT UNIV, MED CTR, DEPT MED, NASHVILLE, TN USA

[3] VANDERBILT UNIV, MED CTR, DEPT CELL BIOL, NASHVILLE, TN USA

[4] UNIV AMSTERDAM, ACAD MED CTR, DEPT PATHOL, 1105 AZ AMSTERDAM, NETHERLANDS

来源：

EUROPEAN JOURNAL OF CANCER | 1995年 / 31A卷 / 7-8期

关键词：

NONSTEROIDAL ANTIINFLAMMATORY DRUGS; NSAIDS; COLORECTAL CANCER; PREVENTION; POLYPS; POLYPOSIS;

D O I：

10.1016/0959-8049(95)00137-8

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Colorectal cancer is the second leading cause of cancer death in the U.S.A. Recent research suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the prevention of colorectal neoplasia. This review summarises the results of research in animals and humans of these compounds in preventing tumours of the colorectum.

引用

页码：1071 / 1076

页数：6

共 55 条

[1]

American Cancer Society, Cancer facts and figures-1990, (1990)

[2]

Fearon, Vogelstein, A genetic model for colorectal tumorigenesis, Cell, 61, (1990)

[3]

Vane, Inhibition of prostaglandin synthesis as a mechanism of action for the aspirin-like drugs, Nature (New Biol), 231, pp. 232-235, (1971)

[4]

Brooks, Wood, Nonsteroidal antiinflammatory drugs—differences and similarities, N Engl J Med, 324, (1991)

[5]

Bishop, Awad, DuBois, Inhibition of immediate early gene expression by sulindac sulfide in rat epithelial cells, Gastroenterology, 106, (1994)

[6]

Kudo, Narisawa, Abo, Antitumor activity of indomethacin on methylazoxymethanol-induced large bowel tumors in rats, Gann, 71, pp. 260-264, (1980)

[7]

Pollard, Luckert, Indomethacin treatment of rats with dimethylhydrazine-induced intestinal tumors, Cancer Treat Rep, 64, pp. 1323-1327, (1980)

[8]

Pollard, Luckert, Effect of indomethacin on intestinal tumors induced in rats by the acetate derivative of dimethylnitrosamine, Science, 214, pp. 558-559, (1981)

[9]

Narisawa, Sato, Tani, Kudo, Takahashi, Goto, Inhibition of development of methylnitrosourea-induced rat colon tumors by indomethacin treatment, Cancer Res, 41, pp. 1954-1957, (1981)

[10]

Narisawa, Sato, Sano, Takahashi, Inhibition of development of methylnitrosourea-induced rat colonic tumors by peroral administration of indomethacin, Gann, 73, pp. 377-381, (1982)

← 1 2 3 4 5 6 →