SULFADIAZINE-INDUCED CRYSTALLURIA IN AIDS PATIENTS WITH TOXOPLASMA ENCEPHALITIS

被引：27

作者：

MOLINA, JM ^{[1
]}

BELENFANT, X ^{[1
]}

DOCOLECOMPTE, T ^{[1
]}

IDATTE, JM ^{[1
]}

MODAI, J ^{[1
]}

机构：

[1] HOP ST LOUIS,DEPT KIDNEY DIS,F-75010 PARIS,FRANCE

来源：

AIDS | 1991年 / 5卷 / 05期

关键词：

AIDS; SULFADIAZINE; CRYSTALLURIA; ALKALINIZATION; RENAL FAILURE; TOXOPLASMA ENCEPHALITIS;

D O I：

10.1097/00002030-199105000-00019

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Toxoplasma encephalitis is the most common opportunistic infection of the central nervous system in patients with AIDS. The treatment of choice is a combination of sulfadiazine and pyrimethamine. We present here four patients with AIDS treated for toxoplasmic encephalitis who developed sulfadiazine-induced crystalluria. This complication was rapidly reversible with rehydration and urine alkalinization. Patients with AIDS treated with high doses of sulfadiazine should be adequately hydrated, and their urinary pH maintained above 7.5 to prevent sulfadiazine-induced crystalluria.

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收藏

页码：587 / 589

页数：3

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