CYTOLYTIC (TIA-1+) TUMOR INFILTRATING LYMPHOCYTES IN B-CELL NON-HODGKINS-LYMPHOMAS

被引：14

作者：

DIAZ, J

TUBBS, R

STOLER, M

GROGAN, T

机构：

[1] Cleveland Clinic Foundation Cleveland, Arizona, OH

[2] SWOG Central Repository Members, H. Lee Moffitt Cancer Center, Arizona, Tucson

[3] University of Arizona, Arizona, Tucson

来源：

LEUKEMIA & LYMPHOMA | 1993年 / 9卷 / 1-2期

关键词：

B-CELL NHL; TILS; CYTOLYTIC; TIA-1;

D O I：

10.3109/10428199309148509

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

TIA-1 is a monoclonal antibody (mAb) that identifies cytolytic cells. We studied eleven B cell non-Hodgkin's lymphomas (NHL) of low grade, eleven B cell NHL of intermediate-high grade, and 10 benign lymphoid hyperplasias (BLH) to investigate potential differences in the number of host cytolytic tumor infiltrating lymphocytes (TILs). Frozen sections were immunostained with TIA-1 mAb and the number of immunoreactive cells (TIA-1+) per mm2 of tissue was quantitated within reactive or neoplastic lymphoid follicles or random areas of diffuse NHL. The number of TIA-1 + cells/mm2 was significantly higher in intermediate and high grade B cell NHL than in low grade NHL or BLH with means +/- se of 1377.8 +/- 173, 866.2 +/- 92.3 and 774.1 +/- 76.2, respectively (p < 0.0183 and p < 0.0125). There was no significant difference between BLH and low grade NHL. The increased number of TIA-1 +/- TILs in B cell NHL of intermediate and high grade suggests the possibility of a host cytolytic immune response versus the tumor. Paradoxically, B cell tumors of worst biological outcome contained more cytolytic TILs. Functional defects of host cytolytic TILs in NHL patients should be investigated in future studies.

引用

页码：91 / 94

页数：4

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