PROFOUND REDUCTION IN ALLERGEN SENSITIVITY FOLLOWING TREATMENT WITH A NOVEL ALLERGY VACCINE

被引:35
作者
HELLMAN, L
机构
[1] Department of Immunology, University of Uppsala, Uppsala
关键词
VACCINE; ALLERGY; IGE; AUTOIMMUNITY;
D O I
10.1002/eji.1830240222
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
A novel approach is described for the treatment of IgE-mediated allergic reactions which is based on the induction of a strong anti-IgE response in the host. Vaccination of ovalbumin-sensitized rats with constant domains two and three of rat IgE coupled to a heterologous carrier protein resulted in a profound decrease in serum levels of IgE, and later in a nearly complete block of histamine release from mast cells and basophils upon challenge with either a cross-linking polyclonal anti-IgE antiserum or a specific allergen.
引用
收藏
页码:415 / 420
页数:6
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