POSITION OF CYCLIZATION IN CYCLIC ADP-RIBOSE

被引：55

作者：

KIM, H

JACOBSON, EL

JACOBSON, MK

机构：

[1] UNIV KENTUCKY,COLL PHARM,DIV MED CHEM & PHARMACEUT,LEXINGTON,KY 40536

[2] UNIV KENTUCKY,DEPT CLIN SCI,LEXINGTON,KY 40536

[3] UNIV KENTUCKY,MARKEY CANC CTR,LEXINGTON,KY 40536

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1993年 / 194卷 / 03期

关键词：

D O I：

10.1006/bbrc.1993.1941

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cyclic adenosine diphosphoribose (cADPR) is a putative second messenger of calcium homeostasis synthesized from NAD by cleavage of the nicotinamide-ribose bond and cyclization of the ribose to the adenine ring. In this study, the ultraviolet absorption spectra of cADPR have been studied as a function of pH and compared to other compounds containing an adenine ring with substitutions at known positions. The results support a structure for cADPR in which cyclization is to position 1 of the adenine ring, rather than to N6, as has been previously proposed. © 1993 Academic Press, Inc.

引用

页码：1143 / 1147

页数：5

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