QSAR STUDY OF BENZOQUINOLINONES AS INHIBITORS OF HUMAN TYPE-1 5-ALPHA-REDUCTASE

被引：3

作者：

WIKEL, JH

BEMIS, KG

AUDIA, JE

MCQUIAD, LA

JONES, CD

PENNINGTON, PA

LAWHORN, DE

HIRSCH, KR

STAMM, NB

机构：

[1] Lilly Research Laboratories, Eli Lilly and Company, Indianapolis

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 06期

关键词：

D O I：

10.1016/S0960-894X(00)80306-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

QSAR models have been developed with regression analysis that related a specific lipophilic feature of the substituent of the molecule with biological activity. A second important feature of the compounds, the energy of the HOMO, was revealed using a simple visualization technique.

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收藏

页码：1157 / 1162

页数：6

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