SONIC HEDGEHOG INDUCES THE DIFFERENTIATION OF VENTRAL FOREBRAIN NEURONS - A COMMON SIGNAL FOR VENTRAL PATTERNING WITHIN THE NEURAL-TUBE

被引：455

作者：

ERICSON, J

MUHR, J

PLACZEK, M

LINTS, T

JESSELL, TM

EDLUND, T

机构：

[1] NATL INST MED RES, LONDON NW7 1AA, ENGLAND

[2] COLUMBIA UNIV, HOWARD HUGHES MED INST, NEW YORK, NY 10032 USA

[3] COLUMBIA UNIV, CTR NEUROBIOL & BEHAV, NEW YORK, NY 10032 USA

来源：

CELL | 1995年 / 81卷 / 05期

关键词：

D O I：

10.1016/0092-8674(95)90536-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The vertebrate hedgehog-related gene Sonic hedgehog (Shh) is expressed in ventral domains along the entire rostrocaudal length of the neural tube, including the forebrain. We show here that SHH induces the differentiation of ventral neuronal cell types in explants derived from prospective forebrain regions of the neural plate. Neurons induced in explants derived from both diencephalic and telencephalic levels of the neural plate express the LIM homeodomain protein Isl-1, and these neurons possess distinct identities that match those of the ventral neurons generated in these two subdivisions of the forebrain in vivo. A single inducing molecule, SHH, therefore appears to mediate the induction of distinct ventral neuronal cell types along the entire rostrocaudal extent of the embryonic central nervous system.

引用

页码：747 / 756

页数：10

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